ChangeWire

Purpose-built diff stream for ClinicalTrials.gov v2 — per-NCT status / enrollment / endpoint / sponsor / eligibility / locations changes as JSONL. Replaces Evaluate Pharma + Citeline + general-purpose scrapers like Browse AI for pharma BI, drug-discovery AI agents, biotech reporters. Public runs.

Purpose-built diff stream for EPA ECHO — facility-flip / violation-class / enforcement-case / CAA/CWA/RCRA/SDWA permit changes as JSONL. ECHO-API-native vocab vs general-purpose scrapers like Browse AI; per-record metered vs Cority $30-200k/yr seat tax for ESG, EJ, journalism, NGOs. Public runs.

Purpose-built FDA Orange Book diff stream — NDA/ANDA/BLA patent listings, exclusivity grants, LoE + TE-code shifts as JSONL. FDA-vocabulary-aware vs general-purpose scrapers like Browse AI; per-record metered vs Cortellis $35-50k/yr seat tax for pharma BI + IP + generics. Public runs.

Purpose-built federal NOFO diff stream — Grants.gov REST API with NIH/NSF/DOE/USDA program-officer + eligibility + close-date diff records as JSONL. Federal-only focus vs Instrumentls nonprofit-foundation breadth; per-record metered ($0.0034) vs Browse AIs $19-249/mo subscription tax. Public runs.

Purpose-built NOAA Storm Events post-event-audit diff — F-scale upgrades, damage revisions, casualty deltas as JSONL. Storm-vocabulary-aware vs Browse AI; per-record metered vs AccuWeather Enterprise / StormGeo / CoreLogic $25-50k/yr seat tax for actuarial + FEMA + litigation cohorts. Public runs.

Purpose-built diff stream for USPTO TTAB — per-proceeding status / filings / parties / marks / deadlines / decisions as JSONL. TTABVUE-API-native vocab vs general-purpose scrapers like Browse AI; per-record metered vs CompuMark $20-200k/yr for trademark counsel + IP litigators. Public runs.